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First published online July 16, 2008, 10.2967/jnumed.108.050849
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Opioid Receptor PET Reveals the Psychobiologic Correlates of Reward Processing

Mathias Schreckenberger1, André Klega1, Gerhard Gründer2,3, Hans-Georg Buchholz1, Armin Scheurich2, Ralf Schirrmacher1,4, Esther Schirrmacher1,4, Christina Müller1, Gjermund Henriksen5 and Peter Bartenstein1,6

1 Department of Nuclear Medicine, Johannes Gutenberg-University, Mainz, Germany; 2 Department of Psychiatry and Psychotherapy, Johannes Gutenberg-University, Mainz, Germany; 3 Department of Psychiatry and Psychotherapy, Aachen University of Technology, Aachen, Germany; 4 Department of Neurology and Neurosurgery, McGill University, Montreal, Canada; 5 Department of Nuclear Medicine, Technical University, Munich, Germany; and 6 Department of Nuclear Medicine, Ludwig Maximilians-University, Munich, Germany


Figure 1
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  		FIGURE 1.  Positive correlation (corrected at cluster level at P < 0.001) between score for reward dependence and opioid receptor availability in bilateral ventral striata with caudate nucleus and nucleus accumbens. Color scale shows t levels, with t = 3.55 corresponding to P = 0.001.

 

Figure 2
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  		FIGURE 2.  Predefined anatomic ROIs of ventral striatum superimposed on clusters significant for reward dependence that are shown in Figure 1.

 

Figure 3
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  		FIGURE 3.  Representative plots of extracted binding potential for right (A) and left (B) ventral striata positively correlated to scores of reward dependence (right, r = 0.81; left, r = 0.84).

 




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