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¹¹¹In-Octreotide Is Superior to ¹²³I-Metaiodobenzylguanidine for Scintigraphic Detection of Head and Neck Paragangliomas

Klaas Pieter Koopmans¹, Pieter L. Jager¹, Ido P. Kema², Michiel N. Kerstens³, Frans Albers^,4 and Robin P.F. Dullaart³

¹ Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; ² Department of Clinical Chemistry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; ³ Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and ⁴ Department of Ear Nose and Throat Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

View larger version (108K): [in this window] [in a new window]   FIGURE 1.  MIBG-negative paraganglioma. (A and B) SRS image (A) shows pathologic uptake (grade 3) in right jaw, whereas on MIBG scan (B) this uptake (grade 1) in not easily identified. (C) MRI coronal slice shows lesion in right jaw.

View larger version (51K): [in this window] [in a new window]   FIGURE 2.  Additional abdominal lesion detected with SRS. (A) SRS image shows uptake in left neck (red arrow, grade 3) and in abdomen, suspected to be due to carcinoid tumor (blue arrow, grade 3). (B) On MIBG scan, neck lesion appears much smaller (red arrow, grade 2) and abdominal lesion shows no uptake (grade 1). (C) SRS and MRI fusion image shows neck lesion.