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First published online April 15, 2008, 10.2967/jnumed.107.049395
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Diastolic Filling Parameters Derived from Myocardial Perfusion Imaging Can Predict Left Ventricular End-Diastolic Pressure at Subsequent Cardiac Catheterization

Dineshkumar Patel1,2, Vincent J.B. Robinson1–3, Roque B. Arteaga1,2 and John W. Thornton1

1 Section of Cardiology, Department of Medicine, Medical College of Georgia, Augusta, Georgia; 2 Specialty Service Line, Charlie Norwood VA Medical Center, Augusta, Georgia; and 3 Department of Radiology, Medical College of Georgia, Augusta, Georgia


Figure 1
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  		FIGURE 1.  Left ventricular diastolic filling curves derived from 4D-MSPECT. (A) Curve with normal diastolic filling parameters. (B) Curve with abnormal diastolic filling parameters. LVEDPs determined at subsequent cardiac catheterization are shown. bpm = beats per minute; EF = ejection fraction; ESV = end-systolic volume; HR = heart rate; LV = left ventricular; MFR3 = filling rate during first third of diastole; PER = peak emptying rate; TPER = time to peak emptying rate; vol = volume.

 

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  		FIGURE 2.  Correlations between 4D-MSPECT diastolic parameters and LVEDP.

 

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  		FIGURE 3.  Correlation between LVEDP and resting 201Tl LHR.

 

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  		FIGURE 4.  ROC curve analysis for ability of PFR (A), TPFR (B), and 1/3FR (C) to detect LVEDPs of ≥18 mm Hg or <18 mm Hg.

 




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