JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online April 15, 2008, 10.2967/jnumed.107.046987
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frost, M. L.
Right arrow Articles by Fogelman, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frost, M. L.
Right arrow Articles by Fogelman, I.

Long-Term Precision of 18F-Fluoride PET Skeletal Kinetic Studies in the Assessment of Bone Metabolism

Michelle L. Frost1, Glen M. Blake1, So-Jin Park-Holohan2, Gary J.R. Cook3, Kathleen M. Curran4, Paul K. Marsden5 and Ignac Fogelman1

1 King's College London, Osteoporosis Screening and Research Unit, Guy's Hospital, London, United Kingdom; 2 Molecular Medicine Section, National Heart and Lung Institute, Imperial College, London, United Kingdom; 3 Department of Nuclear Medicine, Royal Marsden Hospital, London, United Kingdom; 4 School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; and 5 King's College London, PET Imaging Centre, St. Thomas' Hospital, London, United Kingdom


Figure 1
View larger version (35K):
[in this window]
[in a new window]

  		FIGURE 1.  18F-Fluoride PET images of lumbar vertebra showing ROI around vertebral body: transaxial view (image zoomed in inset) (A), sagittal view (B), and coronal view (C).

 

Figure 2
View larger version (4K):
[in this window]
[in a new window]

  		FIGURE 2.  Three-compartmental 4k bone kinetic model described by Hawkins et al. (7) to analyze 18F-fluoride PET bone studies. See text for description of rate constants. RBC = red blood cells; ECF = extracellular fluid.

 

Figure 3
View larger version (9K):
[in this window]
[in a new window]

  		FIGURE 3.  Representative study showing image-derived arterial plasma input function (continuous line) and vertebral ROI time–activity curve ({blacktriangleup}). Vertebral values have been multiplied by 4 for easier comparison with input function. Decay corrections have been applied.

 

Figure 4
View larger version (8K):
[in this window]
[in a new window]

  		FIGURE 4.  Representative Patlak plot. Ki-PAT is equal to slope of normalized tissue activity against normalized time derived using linear regression.

 

Figure 5
View larger version (5K):
[in this window]
[in a new window]

  		FIGURE 5.  Box plot showing differences in repeated measurements for Ki-4k, Ki-3k, and Ki-PAT (A) and for SUVmean (B). Boxes represent values between 25th and 75th percentiles, horizontal bars inside boxes indicate median, vertical bars above and below boxes represent 10th and 90th percentiles, outliers greater than 1.5x interquartile range are presented by circles, and extreme values greater than 3x interquartile range are indicated by asterisk.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2008 by the Society of Nuclear Medicine.