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In Vitro Evaluation of Radioprotective and Radiosensitizing Effects of Rituximab

¹ School of Medicine, The Johns Hopkins University, Baltimore, Maryland; and ² Division of Nuclear Medicine, Russell H. Morgan Department of Radiological Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland

View larger version (23K): [in this window] [in a new window]   FIGURE 1.  (A) Lentivirus transfection cassette. (B) Fluorescence microscopy of transfected cells, demonstrating stable GFP expression. EF1 = elongation factor 1; IRES = internal ribosome entry site; 5'LTR = 5' long terminal repeat; 3'LTR = 3' long terminal repeat; LUC = luciferase.

View larger version (15K): [in this window] [in a new window]   FIGURE 2.  Effect of 1-h rituximab predose (20 µg/mL) on cell survival. Dose–response relationship was observed with regard to cell growth rate in response to various amounts of radiation exposure. Each data point is normalized to starting cell count and represents mean of 3 determinations.

View larger version (16K): [in this window] [in a new window]   FIGURE 3.  Effect of 24-h rituximab predose on cell survival. Dose–response relationship was observed with various amounts of radiation exposure. Each data point is normalized to cell count at day of irradiation and represents mean of 3 determinations.