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Initial Characterization of an ¹⁸F-Labeled Myocardial Perfusion Tracer

¹ Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and ² Department of Discovery Chemistry and Department of Discovery Biology, Bristol Myers Squibb Medical Imaging, North Billerica, Massachusetts

View larger version (17K): [in this window] [in a new window]   FIGURE 1.  Data from first-pass extraction fraction (EF) measurements. Typical time–activity curve (for flow velocity of 8.3 mL/min) is shown, together with extrapolation of fit to tissue washout portion of curve (100 < t [s] < 600; fit itself is not shown). Extraction fraction is defined as ratio of measured (A) to extrapolated (B) values at time point at which measured curve reaches its maximum value (indicated by tmax).

View larger version (15K): [in this window] [in a new window]   FIGURE 2.  First-pass extraction fraction (EF) as function of blood flow. Smoothed time–activity curves obtained from sequential measurements of single rat heart are shown. Flow velocities and extraction fractions are indicated.

View larger version (24K): [in this window] [in a new window]   FIGURE 3.  Late image (15–20 min after injection) of 18F-BMS-747158-02 uptake. Transaxial, coronal, and sagittal views are shown from left to right.

View larger version (16K): [in this window] [in a new window]   FIGURE 4.  PET-derived time–activity curves. (A) Time–activity curves for blood pool and myocardial (Myocard) tissue for animal in stress group. (B) Corresponding time–activity curves for animal in rest group, normalized to same injected dose. Vertical axes are in arbitrary units (a.u.), proportional to cps/mL.

View larger version (7K): [in this window] [in a new window]   FIGURE 5.  Retention values at rest and stress. Retention values determined after 1 min under rest and stress conditions indicated significant increase in blood flow during adenosine infusion. Vertical lines indicate SDs.