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Tumor Imaging Using 1-(2'-deoxy-2'-18F- Fluoro-ß-D-Arabinofuranosyl)Thymine and PET

Omid S. Tehrani1,2, Otto Muzik1,3, Lance K. Heilbrun1, Kirk A. Douglas1,2, Jawana M. Lawhorn-Crews1,2, Haihao Sun1, Thomas J. Mangner1,4 and Anthony F. Shields1,2

1 Karmanos Cancer Institute, Wayne State University, Detroit, Michigan; 2 Department of Medicine, Wayne State University, Detroit, Michigan; 3 Department of Pediatrics, Wayne State University, Detroit, Michigan; and 4 Department of Radiology, Wayne State University, Detroit, Michigan


Figure 1
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  		FIGURE 1.  Scatter plots of tumor SUV at 50–60 min images compared with 5–11 min images. (A) SUVmean. (B) SUVmax. Solid line represents linear regression model. Dashed lines represent 90% confidence limits for predicted mean value of SUV from 50–60 min images for a given value of SUV from 5–11 min images.

 

Figure 2
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  		FIGURE 2.  18F-FMAU images of prostate and brain tumors. (A) 5–11 min. (B) 50–60 min.

 

Figure 3
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  		FIGURE 3.  Plasma analysis HPLC chromatogram depicts activity of each 30-s fraction. Sample is collected at 11 min after injection.

 

Figure 4
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  		FIGURE 4.  Scatter plots comparing TRR and 3-compartment flux. (A) TRR from 11 min images, simplified method using blood vs. flux. (B) TRR from 11 min images using muscle vs. flux. Solid line represents linear regression model. Dashed lines represent 90% confidence limits for predicted mean TRR for a given level of flux.

 




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