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Added Value of Coronary Artery Calcium Score as an Adjunct to Gated SPECT for the Evaluation of Coronary Artery Disease in an Intermediate-Risk Population

¹ Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland; ² Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland; and ³ Zurich Center for Integrative Human Physiology, Zurich, Switzerland

View larger version (17K): [in this window] [in a new window]   FIGURE 1.  Relationship between prevalence and severity of myocardial perfusion abnormalities and extent of coronary artery calcification. n = number of patients in each CAC category who underwent gated SPECT.

View larger version (10K): [in this window] [in a new window]   FIGURE 2.  Relationship between extent of coronary artery calcification and prevalence of significant CAD detected by quantitative coronary angiography (angiographic CAD). n = number of patients in each CAC category who underwent invasive catheterization.

View larger version (10K): [in this window] [in a new window]   FIGURE 3.  ROC curve for detection of significant CAD (50% stenosis) in patients with normal MPI results (n = 42) by use of CAC score. CAC score of greater than or equal to 709 was optimal cutoff for detecting patients with CAD missed by SPECT (arrow). AUC = area under curve.