First published online
July 13, 2007, 10.2967/jnumed.106.036509
Diagnostic and Prognostic Value of 18F-FDG PET/CT for Patients with Suspected Recurrence from Squamous Cell Carcinoma of the Esophagus
Hongbo Guo1,
Hui Zhu2,
Yan Xi3,
Baijiang Zhang1,
Ling Li2,
Yong Huang4,
Jiandong Zhang3,
Zheng Fu4,
Guoren Yang4,
Shuanghu Yuan2 and
Jinming Yu2
1 Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China; 2 Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China; 3 Department of Oncology, Shandong Qianfoshan Hospital, Jinan, Shandong Province, China; and 4 Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China

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FIGURE 1. A 49-y-old male patient with ESCC complained of discomfort of retrosternal burning after esophagectomy. PET/CT scan 4 mo after surgery demonstrated on fusion (A) and serial PET (B) images a positive focus suggestive of recurrence at esophagogastric anastomosis (SUV = 9.8); the lesion was shown to be FP by repeated endoscopy with biopsy.
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FIGURE 2. Whole-body PET/CT in 65-y-old man who received irradiation of primary tumor in upper segment of esophagus and regional lymph nodes in supraclavicular and upper mediastinal area. PET/CT displayed multifocal recurrence. (A) Increased 18F-FDG accumulation remained at primary tumor site (SUV = 6.1), indicating tumor residual disease. (B) Mild focal uptake exhibited in a supraclavicular lymph node with a minor SUV of 2.1. This lesion was subsequently confirmed as malignant by biopsy. (C) Area of abnormally increased uptake was also visible at a left paratracheal lymph node (SUV = 7.8), which proved to be metastatic on follow-up.
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FIGURE 3. Kaplan–Meier curves of OS for 2 subgroups divided according to SUV (cutoff, 9.26). Patients with censored OS times are shown by tick marks.
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FIGURE 4. Kaplan–Meier curves of OS for 3 subgroups stratified by disease pattern according to PET/CT. Patients with censored OS times are shown by tick marks.
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Copyright © 2007 by the Society of Nuclear Medicine.