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Comparison of ¹⁸F-FDG PET and Bone Scintigraphy in Detection of Bone Metastases of Thyroid Cancer

¹ Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; ² Department of Radiology, Toyota Memorial Hospital, Toyota, Japan; ³ Department of Radiological Technology, Nagoya University School of Health Sciences, Nagoya, Japan; ⁴ Department of Radiology, Fujita Health University School of Health Science, Toyoake, Japan; and ⁵ Department of Radiology, Nagoya University Hospital, Nagoya, Japan

View larger version (96K): [in this window] [in a new window]   FIGURE 1.  (A) T1-weighted MR image (left) shows massive lesion of low signal intensity, and T2-weighted MR image (right) shows lesion of high signal intensity. (B) CT scan shows osteolytic changes at thoracic spine (T4–T5). (C and D) 18F-FDG PET coronal image (C) and 99mTc-bone whole-body scintigram (D) show high uptakes at thoracic spine (T4–T5), sacrum, and iliac bones (arrows).

View larger version (34K): [in this window] [in a new window]   FIGURE 2.  In this patient, there were multiple lung metastases besides bone metastases. (A) CT scan shows osteolytic lesions on both sides of iliac bones (arrows). (B) 201Tl SPECT image shows high uptake on both sides of iliac bones (arrows), right lower lung, and left lung hilus (arrowheads). (C) 131I scintigraphy shows no obvious abnormal uptake. (D) 18F-FDG PET shows high uptake on both sides of iliac bones (arrows), right lower lung, and left lung hilus (arrowheads). (E) 99mTc-HMDP bone scintigraphy shows no obvious abnormal uptake.

View larger version (69K): [in this window] [in a new window]   FIGURE 3.  (A) T1-weighted MR image shows metastases at lumbar spine (L3) and sacrum. (B) CT scan shows osteolytic lesions at L3. (C) 99mTc-MDP scan shows high accumulation at thoracic spine (T10), lumbar spine (L3), and iliac bones (arrows), and unlabeled (cold) lesion at left ninth rib (arrowhead). (D) 18F-FDG PET image shows metastases at thoracic spine (T10) and left ribs but no accumulation at L3.