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Diagnostic Performance and Prognostic Value of Extravascular Retention of ¹²³I-Labeled Serum Amyloid P Component in Systemic Amyloidosis

¹ Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; ² Department of Nuclear Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; ³ Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and ⁴ Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

View larger version (18K): [in this window] [in a new window]   FIGURE 1.  PSDI and EVR24 of all 167 patients with systemic amyloidosis (AA, AL, and ATTR types). Patients are subdivided according to intensity of scintigraphic uptake, represented by x (negative, n = 28), (score 1+, n = 45), (score 2+, n = 32), and • (score 3+, n = 62). Dotted lines are reference limits of controls (>0.51 for PSDI and <50% for EVR24), resulting in reference area in upper left quadrant.

View larger version (12K): [in this window] [in a new window]   FIGURE 2.  Relationship between EVR24, serum alkaline phosphatase (A), and endogenous creatinine clearance (B) in patients with AL amyloidosis. Solid lines are linear regression lines.

View larger version (10K): [in this window] [in a new window]   FIGURE 3.  Five-year survival of 80 patients with AL amyloidosis. (A) Patients with (dotted line) and without (solid line) clinical involvement of heart. (B) Patients with high (>50%) (•) and with low (<50%) () EVR24. (C) Patients stratified according to high (>50%) (•) and low (<50%) () EVR24 and presence (dotted line) or absence (solid line) of clinical involvement of heart.