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Optimized, Automated Striatal Uptake Analysis Applied to SPECT Brain Scans of Parkinson's Disease Patients

Institute for Neurodegenerative Disorders, and Molecular Neuroimaging, LLC, New Haven, Connecticut

View larger version (38K): [in this window] [in a new window]   FIGURE 1.  DAT imaging in PD patient followed for 4 y. Visually, there is decreased uptake of radiotracer in striatum, indicative of ongoing loss of presynaptic dopaminergic function. Although the loss is easily noted, it is difficult to determine clinical meaningfulness of this extent of signal change without quantitation.

View larger version (29K): [in this window] [in a new window]   FIGURE 2.  Display showing example patient's brain scan (right half of figure) being registered to standard average scan (left half of figure).

View larger version (30K): [in this window] [in a new window]   FIGURE 3.  Display showing selection of horizontal striatal midplane (left half of figure) and subsequent localization of left and right striatum (right half of figure), both based on location of maxima in either sagittal or coronal profiles.

View larger version (26K): [in this window] [in a new window]   FIGURE 4.  Display showing automatic measurement of head size (left half of figure), whereby distance from midpoint between the 2 striata to edge of occipital lobes is used to scale subsequent ROI placement. Right half of figure shows placement of caudate ROIs (small red circles), putamen ROIs (small yellow circles), and occipital ROI (large truncated annulus).

View larger version (34K): [in this window] [in a new window]   FIGURE 5.  Graph of R value versus combination of N, S, and d parameters used by OSA. R value comes from comparison of OSA V3'' values to those obtained by experienced image processing researcher. Values of N vary from 9 to 15 from left to right along axis; values of s change from 1 to 4 and cycle more slowly from left to right than do values of d, which cycles more quickly through values of 8 to 12.

View larger version (9K): [in this window] [in a new window]   FIGURE 6.  Scatter plot of OSA V3'' evaluations compared with those of experienced researcher for OSA parameters N, s, and d set to 9, 1, and 8, respectively. These parameters yielded optimal slope of 0.93 and demonstrated best accuracy for OSA analysis.

View larger version (10K): [in this window] [in a new window]   FIGURE 7.  Scatter plot of OSA V3'' evaluations compared with those of experienced researcher for OSA parameters N, s, and d set to 13, 0, and 10, respectively. These parameters yielded optimal R value of 0.96 (R2 = 0.93) and demonstrated best precision for OSA analysis.

View larger version (10K): [in this window] [in a new window]   FIGURE 8.  Plot of both R value and regression slope vs. combination of N, S, and d parameters used by OSA. Parameters along horizontal axis are similar to those in Figure 5 in that, here, values of N vary from 3 to 17 from left to right along axis; values of s change from 1 to 4 and cycle more slowly from left to right than do values of d, which cycles more quickly through values of 8 to 12.