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Reproducibility of 18F-FDG microPET Studies in Mouse Tumor Xenografts

Mangal Dandekar*,1, Jeffrey R. Tseng*,1 and Sanjiv S. Gambhir1,2

1 Department of Radiology and the Bio-X Program, Stanford University School of Medicine, Stanford, California; and 2 Department of Bioengineering, Stanford University, Stanford, California


Figure 1
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  		FIGURE 1.  Coronal section of B16F10 nude mouse xenograft scan 1 h (left) and 5 h (right) after single 18F-FDG injection using microPET to show change in tumor activity and tracer distribution over time. Both images are from a single mouse after a single injection of 18F-FDG. This is mouse 5 in Table 2. Mean %ID/g values are shown adjacent to tumor xenograft. Note central photopenia consistent with central necrosis.

 

Figure 2
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  		FIGURE 2.  Coronal section of representative B16F10 nude mouse xenograft scan shows reproducibility of 18F-FDG microPET. This is mouse 3 in Table 1. Initial first scan is shown (left), which is followed by repeat second scan 6 h later (right) after repeat second injection of 18F-FDG. Mean %ID/g values are shown adjacent to tumor xenograft. Arrows point to tumor. Heart also shows high 18F-FDG accumulation in both images.

 

Figure 3
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  		FIGURE 3.  Effect of isoflurane anesthesia on mouse blood glucose levels. Mouse blood glucose levels are plotted as function of time for 6 mice sampled at various times points after initiation of 3% isoflurane anesthesia. Composite logarithmic (log) fit is also displayed (solid black curve).

 




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