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Assessment of ¹¹C-PE2I Binding to the Neuronal Dopamine Transporter in Humans with the High-Spatial-Resolution PET Scanner HRRT

¹ CEA–INSERM U797 Research Unit Neuroimaging in Psychiatry, Service Hospitalier Frédéric Joliot, IFR49, Orsay, and University of Paris-sud, Paris, France; and ² CEA, DRM, DSV, Service Hospitalier Frédéric Joliot, Orsay, France

View larger version (43K): [in this window] [in a new window]   FIGURE 1.  Examples of MRI and PET images. (A) MRI axial planes show delineation of anatomic ROIs in caudate (blue color), putamen (orange color), and cerebellum (green color). (B) Normalized MRI axial plane shows geometric ROIs in midbrain (pink color). (C–E) HRRT and HR+ coregistered frame-summed PET images on axial (left), coronal (middle), and sagittal (right) planes: native HRRT(C), smoothed HRRT (D), and HR+ (E).

View larger version (7K): [in this window] [in a new window]   FIGURE 2.  Distribution plots show relationship between mean striatal BP value and age of subject. BP values resulted from anatomic ROIs in 15 subjects examined with HRRT and 11 subjects examined with HR+.

View larger version (11K): [in this window] [in a new window]   FIGURE 3.  Average time–activity curves, normalized to injected dose (%DI/100 mL) of 11C-PE2I, in dorsal striatum and cerebellum, for age-paired subjects examined with HR+ and HRRT scanners.

View larger version (7K): [in this window] [in a new window]   FIGURE 4.  Distribution plots show relationship between mean midbrain BP values and age of subjects. BP values resulted from "standard-MNI" ROIs in 15 subjects examined with HRRT at spatial resolution of HRRT (native HRRT images) and HR+ (smoothed HRRT images) and 11 subjects examined with HR+.