JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Been, L. B.
Right arrow Articles by Hoekstra, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Been, L. B.
Right arrow Articles by Hoekstra, H. J.

18F-Fluorodeoxythymidine PET for Evaluating the Response to Hyperthermic Isolated Limb Perfusion for Locally Advanced Soft-Tissue Sarcomas

Lukas B. Been1,2, Albert J.H. Suurmeijer3, Philip H. Elsinga1, Pieter L. Jager1, Robert J. van Ginkel2 and Harald J. Hoekstra2

1 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 2 Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and 3 Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands


Figure 1
View larger version (6K):
[in this window]
[in a new window]

  		FIGURE 1.  (A) Correlation between SUVmax and mitotic index before HILP (r = 0.87, P = 0.001). (B) Correlation between SUVmean and mitotic index before HILP (r = 0.82, P = 0.004).

 

Figure 2
View larger version (45K):
[in this window]
[in a new window]

  		FIGURE 2.  Examples of 18F-FLT PET, MRI, and software fusion images of high-grade myxofibrosarcoma before and after HILP. After HILP, this tumor showed 80% necrosis. 18F-FLT PET revealed heterogeneity of tumor before and after HILP.

 

Figure 3
View larger version (13K):
[in this window]
[in a new window]

  		FIGURE 3.  (A) No significant correlation between SUVmax before HILP and percentage of necrosis after HILP (r = 0.622, P = 0.055). (B) Correlation between SUVmean before HILP and percentage of necrosis after HILP (r = 0.642, P < 0.05). These data indicated that tumors with high initial 18F-FLT uptake showed better response to HILP. (C) No significant correlation between decrease in SUVmax and percentage of necrosis after HILP (r = 0.190, P = 0.60). (D) No significant correlation between decrease in SUVmean and percentage of necrosis after HILP (r = 0.404, P = 0.25).

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2007 by the Society of Nuclear Medicine.