Quantification of Striatal Dopamine Transporters with 123I-FP-CIT SPECT Is Influenced by the Selective Serotonin Reuptake Inhibitor Paroxetine: A Double-Blind, Placebo-Controlled, Crossover Study in Healthy Control Subjects
Jan Booij1,2,
Jan de Jong1,
Kora de Bruin1,
Remco Knol1,2,
Maartje M.L. de Win2,3 and
Berthe L.F. van Eck-Smit1
1 Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; 2 Graduate School for Neurosciences, Amsterdam, The Netherlands; and 3 Department of Radiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
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FIGURE 1. Planar scintigraphy of lung uptake of 123I-FP-CIT in healthy young male volunteer, at placebo session (left) and paroxetine session (right). Lung uptake is clearly visible after placebo but not after paroxetine. Activity is encoded from high (black) to low (white). Template with fixed ROIs for lungs and shoulder is shown on the left.
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FIGURE 2. Transversal slices of 123I-FP-CIT SPECT scan, obtained in healthy young male volunteer 1 h after injection of radiotracer (placebo pretreatment). Intense and symmetric uptake is visualized in striatum. Binding is also visualized in midbrain and diencephalon area, which is higher than activity in cerebellum and cortical areas but much lower than binding in striatum. Activity is color encoded from high (white) to low (black).
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FIGURE 3. Transversal slices of 123I-FP-CIT SPECT scan at level of temporal cortex and midbrain, obtained in healthy young male volunteer 3 h after injection of radiotracer. After placebo pretreatment there is clear visualization of activity in midbrain (left), which is much lower after paroxetine pretreatment (right). Activity is color encoded from high (white) to low (black).
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Copyright © 2007 by the Society of Nuclear Medicine.
