HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Higuchi, T. Articles by Bengel, F. M. Search for Related Content PubMed PubMed Citation Articles by Higuchi, T. Articles by Bengel, F. M.

Characterization of Normal and Infarcted Rat Myocardium Using a Combination of Small-Animal PET and Clinical MRI

Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany

View larger version (38K): [in this window] [in a new window]   FIGURE 1.  Short-axis images of normal rat heart with 18F-FDG uptake and cine MRI at end-diastolic (ED) and end-systolic (ES) phases. Serial images from apex (left) to base (right) are shown.

View larger version (36K): [in this window] [in a new window]   FIGURE 2.  Polar maps of normal distributions of 18F-FDG uptake in healthy rats. Mean percentage uptake is almost homogeneous throughout LV wall but slightly decreased at apex. Ant = anterior; Sep = septal; Lat = lateral; Inf = inferior.

View larger version (35K): [in this window] [in a new window]   FIGURE 3.  (A) Short-axis images from apex (left) to base (right) in rat with permanent left coronary occlusion (1 d after myocardial infarction). 18F-FDG PET shows an uptake defect, and delayed-enhancement MRI (ce-MRI) demonstrates hyperenhanced area in corresponding anterior wall indicated by fused images (arrows). Corresponding histologic sections stained with hematoxylin–eosin reveal the infarct area as a poorly stained area. (B) Polar map views of 18F-FDG uptake (left) and of infarct area (blue) determined by threshold analysis using 6 SDs (right). Examples of tracing of LV region (red) and infarct area (blue) are displayed in C (ce-MRI) and D (histology).

View larger version (17K): [in this window] [in a new window]   FIGURE 4.  Linear regression analysis between percentage LV delayed-enhancement area by ce-MRI and percentage LV infarct size of ex vivo analysis (A) and between percentage LV defect area of 18F-FDG PET (threshold analysis by –6 SDs of normal data base) and percentage LV infarct size (B) in myocardial infarction model of rat. •, 1 wk after MI; , 1 d after MI.

View larger version (39K): [in this window] [in a new window]   FIGURE 5.  Myocardial images of 18F-FDG PET and ce-MRI from a rat with coronary occlusion (20 min), which was followed by reperfusion. 18F-FDG was administrated under a fasting condition 24 h after coronary reperfusion. Increased 18F-FDG uptake is seen (arrow), corresponding to the area of delayed enhancement on ce-MRI (arrow).