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First published online September 14, 2007, 10.2967/jnumed.107.042317
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123I-5-IA-85380 SPECT Imaging of Nicotinic Acetylcholine Receptor Availability in Nonsmokers: Effects of Sex and Menstrual Phase

Kelly P. Cosgrove1,2, Effie M. Mitsis1,2, Frederic Bois1,2, Erin Frohlich1,2, Gilles D. Tamagnan1,3, Erica Krantzler1,2, Edward Perry1,2, Paul K. Maciejewski1, C. Neill Epperson1, Sharon Allen4, Stephanie O'Malley1, Carolyn M. Mazure1, John P. Seibyl3, Christopher H. van Dyck1 and Julie K. Staley1,2

1 Yale University School of Medicine, New Haven, Connecticut; 2 Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; 3 Institute for Neurodegenerative Disorders, New Haven, Connecticut; and 4 University of Minnesota, Minneapolis, Minnesota


Figure 1
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  		FIGURE 1.  123I-5-IA activity is shown in 10 men ({circ}) and 19 women (•) in 3 selected brain regions: thalamus, cortex (average of cortical regions), and cerebellum. Top row depicts data as kBq/cm3 uncorrected for metabolism or protein binding, middle row is VT', and bottom row is VT.*P values < 0.00625 are significant after Bonferroni correction.

 

Figure 2
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  		FIGURE 2.  Mean parametric images illustrating 123I-5-IA activity in 10 men and 19 women in VT' and VT.

 

Figure 3
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  		FIGURE 3.  Radiotracer metabolism and protein binding are shown in 10 men ({circ}) and 19 women (•).

 

Figure 4
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  		FIGURE 4.  (Top) Within-subject 123I-5-IA activity (VT) in thalamus, cortex (average of cortical regions), and cerebellum in 9 nonsmoking women in early follicular and mid-luteal phases of menstrual cycle. (Bottom) Radiotracer metabolism and protein binding in same women in early follicular ({circ}) and mid-luteal (•) phases of menstrual cycle. No significant differences in VT, total parent, f1, or free parent were found between early follicular and mid-luteal phases of menstrual cycle.

 




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