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First published online September 14, 2007, 10.2967/jnumed.107.043406
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18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Feng-Yuan Liu1, Chien-Yu Lin2, Joseph T. Chang2, Shu-Hang Ng3, Shy-Chyi Chin3, Hung-Ming Wang4, Chun-Ta Liao5, Sheng-Chieh Chan1 and Tzu-Chen Yen1

1 Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan; 2 Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan; 3 Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan; 4 Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan; and 5 Department of Otorhinolaryngology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan


Figure 1
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  		FIGURE 1.  Patient-based comparison of ROC curves for 18F-FDG PET and CWU in primary M staging of NPC patients.

 

Figure 2
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  		FIGURE 2.  Patient-based comparison of ROC curves for 18F-FDG PET and PET+CWU in primary M staging of NPC patients.

 

Figure 3
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  		FIGURE 3.  A 69-y-old woman who was a patient with NPC of stage T2 N3. (A) Skeletal scintigraphy revealed no evidence of bone metastasis. (B) Maximum-intensity-projection image of 18F-FDG PET revealed multiple metastases in skeletal system. Patient died of disease 11 mo later.

 

Figure 4
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  		FIGURE 4.  A 49-y-old man who was a patient with NPC of stage T4 N2. (A) Chest radiography revealed no evidence of chest metastasis. (B) Maximum-intensity-projection image of 18F-FDG PET revealed focal metastasis in right lower chest. CT-guided biopsy of 0.8-cm nodule in right lower lung confirmed it to be a metastatic tumor.

 




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