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^99mTc- and ¹¹¹In-Labeled -Melanocyte-Stimulating Hormone Peptides as Imaging Probes for Primary and Pulmonary Metastatic Melanoma Detection

¹ College of Pharmacy, University of New Mexico, Albuquerque, New Mexico; ² Department of Biochemistry, University of Missouri-Columbia, Columbia, Missouri; ³ Department of Radiology, University of Missouri-Columbia, Columbia, Missouri; and ⁴ Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri

View larger version (7K): [in this window] [in a new window]   FIGURE 1.  Schematic structures of 99mTc-(Arg11)CCMSH (A) and 111In-DOTA-Re(Arg11)CCMSH (B).

View larger version (25K): [in this window] [in a new window]   FIGURE 2.  Whole-body and transaxial images of 99mTc-(Arg11)CCMSH (A and B, respectively) and 111In-DOTA-Re(Arg11)CCMSH (D and C, respectively) in B16/F1 flank melanoma-bearing C57 mice at 2 h after injection. Whole-body and transaxial images of 99mTc-(Arg11)CCMSH (E and F, respectively) and 111In-DOTA-Re(Arg11)CCMSH (H and G, respectively) in B16/F10 pulmonary metastatic melanoma-bearing C57 mice 2 h after injection.