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A Preliminary Study of Anti-1-Amino-3-¹⁸F-Fluorocyclobutyl-1-Carboxylic Acid for the Detection of Prostate Cancer

¹ Research Center, Nihon Medi-Physics Co., Ltd., Sodegaura, Chiba, Japan; and ² PET Center and Department of Radiology, Emory University, Atlanta, Georgia

View larger version (9K): [in this window] [in a new window]   FIGURE 1.  Time course of anti-18F-FACBC and 18F-FDG uptake into DU145 in absence (A) or presence (B) of rat plasma concentration of natural amino acids and D-glucose. Each point represents mean ± SD (n = 3).

View larger version (97K): [in this window] [in a new window]   FIGURE 2.  Anti-18F-FACBC (A) and 18F-FDG (C) autoradiographs and corresponding sections (B and D, respectively; H–E staining) of prostate from OPCT rats. PCa region is represented with a red dash line.

View larger version (57K): [in this window] [in a new window]   FIGURE 3.  (A and B) Dynamic transverse (Trans.) images of PCa region from FACBC microPET scan (A) and FDG microPET scan (B) of OPCT model and coronal (Cor.)/sagittal (Sag.) images corresponding to transverse section. Red and yellow arrows represent the PCa and urinary bladder, respectively. (C and D) Autopsy specimens of prostate of OPCT rats used for FACBC microPET (C) and FDG microPET (D) imaging studies. PCa region is represented with a red dashed line.

View larger version (17K): [in this window] [in a new window]   FIGURE 4.  (A) Time–activity curves of anti-18F-FACBC (n = 3) and 18F-FDG (n = 1) for PCa, muscle, pancreas, blood, and urinary bladder from OPCT rats. (B) Time course of anti-18F-FACBC (n = 3) and 18F-FDG (n = 1) uptake ratios of PCa to muscle, PCa to blood, PCa to pancreas, and PCa to bladder.

View larger version (16K): [in this window] [in a new window]   FIGURE 5.  Comparison of uptake of anti-18F-FACBC and 18F-FDG at 60 min after injection into normal popliteal lymph node (LN, intact), popliteal lymphadenitis (LN, inflammation, 3 d after STZ stimulation), and subcutaneous PCa in DPCI model. *P < 0.01; P = not significant. Each bar represents mean ± SD (n = 4).

View larger version (19K): [in this window] [in a new window]   FIGURE 6.  Comparison of anti-18F-FACBC and 18F-FDG uptake (%ID/g) into prostate lobes of normal, BPH, and DPCI rats. *P < 0.01; P < 0.05; P = not significant. Each bar represents mean ± SD (n = 3–6).