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Extended Studies of the Striatal Uptake of 99mTc-NC100697 in Healthy Volunteers

Walter Koch1, Oliver Pogarell2, Gabriele Pöpperl1, Julia Hornung1, Christine Hamann3, Franz-Josef Gildehaus1, Klaus Seelos4, Dewi Lewis5, Antonella Favit5 and Klaus Tatsch1

1 Department of Nuclear Medicine, University of Munich, Munich, Germany; 2 Department of Psychiatry, University of Munich, Munich, Germany; 3 Department of Neurology, University of Munich, Munich, Germany; 4 Department of Neuroradiology, University of Munich, Munich, Germany; and 5 GE Healthcare, Amersham, United Kingdom


Figure 1
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  		FIGURE 1.  Example of time course of brain counts and image quality in 24.5-y-old female healthy participant after injection (p.i.) of 789 MBq 99mTc-NC100697.

 

Figure 2
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  		FIGURE 2.  Individual time course (decay corrected) of specific striatal binding (A), counts in striatal region (B, solid line) and counts in occipital reference region (B, dashed line), and group mean specific striatal binding (C), all based on manual 2D ROI approach.

 

Figure 3
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  		FIGURE 3.  Age dependency of specific striatal binding (based on automated 3D VOI evaluation method), fitted with broken-stick regression model (A), with linear (B, dashed line) and logarithmic regression models (B, solid line).

 

Figure 4
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  		FIGURE 4.  Profiles of age dependency of DAT binding in women (A) and in men (C). (B) Mean ± SD of DAT binding for each age cohort, where striatal binding in women is represented by dashed line and that of male subjects by solid line.

 

Figure 5
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  		FIGURE 5.  Example of subjects with high (A) and low (B) striatal binding. (C) Putamen-to-caudate ratios remained stable throughout the full age range.

 




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