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Fabrication and Characterization of a 0.5-mm Lutetium Oxyorthosilicate Detector Array for High-Resolution PET Applications

Jennifer R. Stickel1, Jinyi Qi2 and Simon R. Cherry2

1 Department of Radiology, School of Medicine, University of California Davis Medical Center, Davis, California; and 2 Department of Biomedical Engineering, University of California, Davis, Davis, California


Figure 1
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  		FIGURE 1.  Photograph of one of two 0.43 x 0.43 x 10 mm LSO arrays fabricated. Each array has 20 x 30 elements.

 

Figure 2
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  		FIGURE 2.  (A) Flood histogram obtained by uniform irradiation of one array with a 68Ge source. (B) Crystal lookup table generated from this flood histogram using a semiautomated watershed algorithm. Central crystals are easily separated, whereas edge and corner crystals require some manual estimation of borders.

 

Figure 3
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  		FIGURE 3.  Energy spectra for 4 representative crystals in the array. The x-axis shows energy in arbitrary units. FWHM energy resolution for crystal 1 is unmeasurable, whereas the others measure 38% (crystal 8), 23% (crystal 260), and 22% (crystal 253).

 

Figure 4
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  		FIGURE 4.  Timing spectrum for the 2 LSO detectors in coincidence. FWHM is 1.42 ns and FWTM is 3.12 ns.

 

Figure 5
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  		FIGURE 5.  Intrinsic spatial resolution profile as measured with 30-gauge needle filled with 18F. FWHM resolution is 0.68 mm. Profile shown here is sum of the profiles for 10 crystals in a row along each detector leading to 100 individual profiles.

 

Figure 6
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  		FIGURE 6.  Images of line source phantom obtained using 0.5-mm detectors (A), microPET II scanner (B), and microPET Focus scanner (C) using filtered backprojection reconstruction with a ramp filter. All sources can be clearly resolved only with the high-resolution detector.

 

Figure 7
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  		FIGURE 7.  Projection image of a mouse foot acquired with two 0.5-mm LSO detectors using 18F– as radiotracer. Photograph of a mouse foot, with a millimeter-scale ruler as reference, is also shown.

 




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