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Troponin I Overexpression Inhibits Tumor Growth, Perfusion, and Vascularization of Morris Hepatoma

Kerstin Schmidt1–3,, Johannes Hoffend3, Annette Altmann2,3, Fabian Kiessling4, Ludwig Strauss2,3, Dirk Koczan5, Walter Mier3, Michael Eisenhut6, Ralf Kinscherf*,1 and Uwe Haberkorn*,2,3

1 Department of Anatomy and Cell Biology III, University of Heidelberg, INF 307, Heidelberg, Germany; 2 Clinical Cooperation Unit Nuclear Medicine, DKFZ and University of Heidelberg, INF 280, Heidelberg, Germany; 3 Department of Nuclear Medicine, University of Heidelberg, INF 400, Heidelberg, Germany; 4 Department of Biophysics and Medical Radiation Physics, DKFZ, INF 280, Heidelberg, Germany; 5 Department of Immunology, University of Rostock, Rostock, Germany; and 6 Department of Radiopharmaceutical Chemistry, DKFZ, INF 280, Heidelberg, Germany


Figure 1
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  		FIGURE 1.  Expression of TnI in clones of MH3924A. (A) Northern blot. (B) Western blot. Representative blots are shown. {alpha}-Tubulin or ß-actin was used as internal control. bp = base pairs.

 

Figure 2
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  		FIGURE 2.  Proliferation and apoptosis of HUVECs cocultured with WT-MH3924A or TnI-MH3924A cells. (A) Proliferation. (B) Apoptosis. Values are mean ± SEM. *P < 0.05 vs. WT-MH3924A.

 

Figure 3
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  		FIGURE 3.  Tumor growth of WT-MH3924A and TnI-MH3924 tumors until 40 d after inoculation. Values are mean ± SEM. ***P < 0.001; **P < 0.01; *P < 0.05 vs. WT-MH3924A.

 

Figure 4
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  		FIGURE 4.  H215O PET. Representative images and time–activity curves measured in WT-MH3924A (A and C) and TnI-MH3924A (B and D) tumor; 2-dimensional acquisition. Results of modeling analysis are shown in Table 2. T = tumor.

 

Figure 5
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  		FIGURE 5.  Functional MRI. Representative T2-weighted images of WT-MH3924A (A) and TnI-MH3924A (B) tumor. Corresponding parametric images for A and kep are shown in C and D. Range of signal intensity for kep and A is indicated at bottom.

 




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