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Dosimetry in Peptide Radionuclide Receptor Therapy: A Review*

Marta Cremonesi1, Mahila Ferrari1, Lisa Bodei2, Giampiero Tosi1 and Giovanni Paganelli2

1 Division of Medical Physics, European Institute of Oncology, Milan, Italy; and 2 Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy


Figure 1
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  		FIGURE 1.  Dosimetric data published for principal PRRT trials: (A) 111In-DTPA-octreotide (Stabin (13), Forster (22), Helish (23), Kwekkeboom (14)). (B) 90Y-DOTATOC (Cremonesi (15), Forster (22), Helish (23), Forrer (16)). (C) 177Lu-DOTATATE (Kwekkeboom (30)). Large ranges of variability emerge, even in large cohort of patients. This suggests that mean values of absorbed doses among patients should not be the only criterion to plan PRRT. Besides the methods used for dosimetry, interindividual differences are attributable, especially to organ functionality, metabolism, or receptor density in organs.

 




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