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The So-Called Stunning of Thyroid Tissue

James C. Sisson1, Anca M. Avram1, Susan A. Lawson1, Paul G. Gauger2 and Gerard M. Doherty2

1 Division of Nuclear Medicine, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan; and 2 Division of Endocrine Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan


Figure 1
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FIGURE 1.  131I disappearance from thyroid tissues over time (see text for descriptions of patterns). Group A: patients 1, 2, and 5–8 in whom Rx/Dx was <0.6 at 2 d. During the first day Rx/Dx was near unity in all but patient 7; group B: patients 3 and 10 in whom Rx/Dx was >0.6 at 2 d and in whom Rx/Dx values changed modestly over time; and group C: patients 4 and 9 in whom Rx/Dx levels were >1.0 at 2 d. For each subject the diagnostic dose was 1 mCi (37 MBq); therapeutic dose is expressed on each graphic plot. In patients 1, 2, and 4–6, the first and second components of therapeutic disappearance of 131I are inscribed and designated k1 and k2, respectively.

 

Figure 2
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FIGURE 2.  Disappearance of therapeutic 131I from bodies of patients over time. Composites are of groups A, B, and C (Fig. 1).

 





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