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Response-Dependent Differences in Regional Cerebral Blood Flow Changes with Citalopram in Treatment of Major Depression

Alexius Y. Joe1, Thomas Tielmann1, Jan Bucerius1, Michael J. Reinhardt1, Holger Palmedo1, Wolfgang Maier2, Hans-Juergen Biersack1 and Astrid Zobel2

1 Department of Nuclear Medicine; University of Bonn, Bonn, Germany; and 2 Department of Psychiatry; University of Bonn, Bonn, Germany


Figure 1
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FIGURE 1.  Statistical parametric Z maps (height threshold, P < 0.005; voxel threshold, k > 100) show cluster of significant lower rCBF in responders compared with that of nonresponders in beginning of treatment (t1). See Table 2 for details of Talairach coordinates.

 

Figure 2
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FIGURE 2.  Changes in rCBF after 4 wk of treatment (t2) (height threshold, P < 0.005; voxel threshold, k > 100). (A) Cluster of significant increase in rCBF in nonresponders. (B) Clusters of significant decrease in rCBF in responders. (C) Cluster of significant opposite directed courses in rCBF in both groups. See Tables 3–5Go for details of Talairach coordinates.

 





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