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Noninvasive Measurement of Cardiovascular Function in Mice with High-Temporal-Resolution Small-Animal PET

Michael C. Kreissl1, Hsiao-Ming Wu1, David B. Stout2, Waldemar Ladno2, Thomas H. Schindler1, Xiaoli Zhang1, John O. Prior1, Mayumi L. Prins3, Arion F. Chatziioannou2, Sung-Cheng Huang1 and Heinrich R. Schelbert1

1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California; 2 Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California; and 3 Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California


Figure 1
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  		FIGURE 1.  Example of LV time–activity curve and exponential fit correcting for recirculation. Area under upslope of LV time–activity curve and exponentially fitted downslope is finite.

 

Figure 2
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  		FIGURE 2.  Consecutive 0.3-s frames show passage of tracer bolus through RV cavity, lungs, and LV chamber of mouse on coronal and transverse slices. Times are those after start of image acquisition. For better anatomic orientation, PET scan is overlaid with coregistered CT scan.

 

Figure 3
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  		FIGURE 3.  Time–activity curves derived for VOIs placed in RV and LV chamber and over whole body (total count on secondary y-axis).

 

Figure 4
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  		FIGURE 4.  Correlations between cardiac output, cardiac index, and heart rate.

 

Figure 5
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  		FIGURE 5.  Results of repeated measurements of heart rate (A), cardiac output (B), and stroke volume (C) in 5 mice.

 

Figure 6
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  		FIGURE 6.  Individual changes in heart rate (A), cardiac output (B), and stroke volume (C) from baseline to dobutamine stress in 4 mice.

 




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