JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, W.
Right arrow Articles by Cloughesy, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, W.
Right arrow Articles by Cloughesy, T.

18F-FDOPA PET Imaging of Brain Tumors: Comparison Study with 18F-FDG PET and Evaluation of Diagnostic Accuracy

Wei Chen1,2, Daniel H.S. Silverman1, Sibylle Delaloye1, Johannes Czernin1, Nirav Kamdar1, Whitney Pope3, Nagichettiar Satyamurthy1, Christiaan Schiepers1 and Timothy Cloughesy4

1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; 2 Department of Radiology, Kaiser Permanente Woodland Hills Medical Center, Woodland Hills, California; 3 Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; and 4 Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California


Figure 1
View larger version (19K):

[in a new window]
  		FIGURE 1.  Time–activity curves for tracer uptake on 18F-FDOPA PET scans summarized for 11 patients over 75 min from time of injection. (A) Time course of tracer accumulation in tumor tissue, cerebellum, and striatum. Tumor uptake is expressed as mean values of voxels with top 20% SUVs. Error bars denote 1 SE from mean uptake. (B) Time course of tracer accumulation in tumor tissue, cortex, and white matter. Error bars denote 1 SE from mean uptake.

 

Figure 2
View larger version (108K):

[in a new window]
  		FIGURE 2.  MRI (left), 18F-FDG PET (middle), and 18F-FDOPA PET (right) of newly diagnosed tumors. (A) Glioblastoma. (B) Grade II oligodendroglioma.

 

Figure 3
View larger version (108K):

[in a new window]
  		FIGURE 3.  MRI (left), 18F-FDG PET (middle), and 18F-FDOPA PET (right) for evaluating recurrent tumors. (A) Recurrent glioblastoma. (B) Recurrent grade II oliogodendroglioma.

 

Figure 4
View larger version (12K):

[in a new window]
  		FIGURE 4.  (A) Box plots of 18F-FDOPA T/N values in high-grade and low-grade brain tumors and radiation necrosis. There was no statistically significant difference between high-grade and low-grade tumors (P = 0.40). There was a statistically significant difference between tumors and radiation necrosis (P < 0.00001). Error bars indicate SEs. (B) Box plots of 18F-FDOPA T/N values in brain tumors that were contrast enhancing on MRI (CE) and those that did not take up contrast material on MRI (NCE). No statistical difference was seen between CE and NCE tumors (P = 0.40). Statistically significant difference was seen between CE tumors and radiation necrosis (P < 0.00001). Error bars indicate SEs.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2006 by the Society of Nuclear Medicine.