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Iodine Biokinetics and Dosimetry in Radioiodine Therapy of Thyroid Cancer: Procedures and Results of a Prospective International Controlled Study of Ablation After rhTSH or Hormone Withdrawal

Heribert Hänscheid, PhD1, Michael Lassmann, PhD1, Markus Luster, MD1, Stephen R. Thomas, PhD2, Furio Pacini, MD3,4, Claudia Ceccarelli, MD3, Paul W. Ladenson, MD5, Richard L. Wahl, MD6, Martin Schlumberger, MD7, Marcel Ricard, PhD7, Al Driedger, MD8, Richard T. Kloos, MD9, Steven I. Sherman, MD10, Bryan R. Haugen, MD11, Vincent Carriere, PhD12, Carine Corone, MD12 and Christoph Reiners, MD1

1 Klinik und Poliklinik für Nuklearmedizin, Universität Würzburg, Würzburg, Germany; 2 Department of Radiology, University of Cinncinati, Cinncinati, Ohio; 3 Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy; 4 Section of Endocrinology, Department of Internal Medicine, Endocrinology and Metabolism, University of Siena, Siena, Italy; 5 Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland; 6 Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; 7 Service de Medicine Nucleaire et de Cancerologie Endocrinienne, Institut Gustave Roussy, Villejuif, France; 8 Department of Nuclear Medicine, London Health Sciences Centre, London, Ontario, Canada; 9 Divisions of Endocrinology and Nuclear Medicine, Departments of Internal Medicine and Radiology, The Ohio State University, Columbus, Ohio; 10 Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 11 Division of Endocrinology, Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado; and 12 Department of Nuclear Medicine, Centre Rene Huguenin, Saint Cloud, France


Figure 1
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  		FIGURE 1.  Whole-body and neck images including ROIs to be drawn.

 

Figure 2
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  		FIGURE 2.  Activity in whole body ({circ}, scintillation camera; •, probe measurements), remnant ({diamond}), and blood ({blacktriangleup}) of the first patient treated according to the protocol as a function of time after administration.

 

Figure 3
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  		FIGURE 3.  Remnant iodine kinetics in rhTSH group ({blacklozenge}) and THW group ({diamond}).

 

Figure 4
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  		FIGURE 4.  Specific blood dose values in rhTSH group ({blacklozenge}) and THW group ({diamond}).

 




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