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Assessment of Myocardial Blood Flow Using 15O-Water and 1-11C-Acetate in Rats with Small-Animal PET

Pilar Herrero, MS, Joonyoung Kim, PhD, Terry L. Sharp, RT(R), John A. Engelbach, Jason S. Lewis, PhD, Robert J. Gropler, MD and Michael J. Welch, PhD

Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri


Figure 1
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  		FIGURE 1.  Factor images of LV, RV, and myocardium and their corresponding factors obtained from PET cardiac images of 15O-water (A) or 1-11C-acetate (B) from rats studied at rest.

 

Figure 2
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  		FIGURE 2.  Correlation between MBF estimated from 15O-water and MBF measured directly using radiolabeled microspheres (MIC) (A) and the corresponding residual plot (B). Mean residual error (MRE) was calculated as the average of the absolute difference between measured and predicted MBF values from the regression analysis in A. •, resting perfusion; {triangleup}, perfusion during dobutamine; {blacksquare}, perfusion during propranolol infusion.

 

Figure 3
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  		FIGURE 3.  Correlation between MBF estimates shown in Figure 2 after forcing the intercept to zero (A) and the corresponding residual plot (B). Mean residual error (MRE) was calculated as the average of the absolute difference between measured and predicted MBF values from the regression analysis in A. •, resting perfusion; {triangleup}, perfusion during dobutamine; {blacksquare}, perfusion during propranolol infusion. MIC = radiolabeled microspheres.

 

Figure 4
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  		FIGURE 4.  Representative blood and myocardial time–activity curves for 15O-water and 1-11C-acetate for low (A), medium (B), and high (C) MBF values. TAC = time–activity curve.

 

Figure 5
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  		FIGURE 5.  Correlation between K1 estimated from 1-11C-acetate and MBF estimated from 15O-water (A) and the corresponding residual plot as a function of 15O-water MBF (B). Mean residual error (MRE) was calculated as the average of the absolute difference between measured and predicted MBF values from the regression analysis in A.

 

Figure 6
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  		FIGURE 6.  Correlation between MBF estimated from 1-11C-acetate and MBF estimated from 15O-water (A) and the corresponding residual plot as a function of 15O-water MBF (B). No significant residual bias was observed. Mean residual error (MRE) was calculated as the average of the absolute difference between measured and predicted MBF values from the regression analysis in A.

 




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