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Renal Uptake of Radiolabeled Octreotide in Human Subjects Is Efficiently Inhibited by Succinylated Gelatin

Erik Vegt, MD1, Jack F.M. Wetzels, MD, PhD2, Frans G.M. Russel, PhD3, Rosalinde Masereeuw, PhD3, Otto C. Boerman, PhD1, Juliette E. van Eerd, PhD1, Frans H.M. Corstens, MD, PhD1 and Wim J.G. Oyen, MD, PhD1

1 Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; 2 Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; and 3 Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands


Figure 1
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  		FIGURE 1.  %ID (mean ± SD) of 111In-OCT over time in kidneys at baseline or after infusion of GELO. Significantly less 111In-OCT was retained in kidneys after GELO infusion than after normal saline infusion (P = 0.006 for difference in areas under curves).

 

Figure 2
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  		FIGURE 2.  %ID (mean ± SD) of 111In-OCT over time in kidneys at baseline or after infusion of HES. No statistically significant difference was observed between infusion of normal saline and infusion of HES.

 

Figure 3
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  		FIGURE 3.  Posterior images of kidney region 24 h after injection of 111In-OCT at baseline (A) and after GELO infusion (B) and at baseline (C) and after HES infusion (D). GELO resulted in renal uptake levels lower than those at baseline, whereas HES had no effect.

 

Figure 4
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  		FIGURE 4.  Clearance of 111In-OCT from blood over time. No statistically significant differences were observed between groups.

 




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