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Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy

Oliver Lindner, MD1, Jens Sörensen, MD, PhD2, Jürgen Vogt, MD3, Eva Fricke, MD1, Detlev Baller, MD, PhD3, Dieter Horstkotte, MD, PhD3 and Wolfgang Burchert, MD, PhD1

1 Institute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany; 2 Clinical Physiology, Department of Medical Sciences, Academic Hospital, Uppsala, Sweden; and 3 Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany


Figure 1
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  		FIGURE 1.  Right ventricular activity concentration curve after bolus injection. Dotted line represents monoexponential fit to downslope of activity concentration curve with forward extrapolation to correct for recirculation. Cardiac output is calculated as injected dose divided by area under concentration curve corrected for recirculation.

 

Figure 2
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  		FIGURE 2.  Acetate clearance rate k2, a measure of MVO2 rate (A); coefficient of variation of k2 between myocardial walls (B); SVI (C); cardiac efficiency in patients with severe heart failure and LBBB (n = 16) at baseline, after 4 mo, and after 13 mo of CRT (D). Values are mean ± SD. *P < 0.05 vs. 4 mo and 13 mo of CRT. Dotted horizontal line indicates mean value of corresponding parameter of comparison group with mild heart failure patients without LBBB (n = 13) and dashed lines indicate mean ± SD.

 




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