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PET Imaging of Serotonin Transporters with [¹¹C]DASB: Test–Retest Reproducibility Using a Multilinear Reference Tissue Parametric Imaging Method

¹ Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland; ² Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and ³ Nuclear Medicine Division, Brain Molecular Imaging Program, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

View larger version (45K): [in a new window]   FIGURE 1.  Test (left column) and retest (right column) parametric images of BP (top row) and R1 (bottom row) of a representative subject. Th = thalamus; Ra = raphe; Hyp = hypothalamus; Cg = cingulate gyrus.

View larger version (52K): [in a new window]   FIGURE 2.  MRI superimposed with t-statistic maps obtained from SPM comparing test and retest studies using height threshold of uncorrected P = 0.05 and extent threshold of 100 voxels. (A) t-statistic maps comparing BP values of test and retest (test > retest). (B) t-statistic maps comparing R1 values of test and retest (test < retest).