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18F-CPFPX PET: On the Generation of Parametric Images and the Effect of Scan Duration

Philipp T. Meyer, MD, David Elmenhorst, MD, Andreas Matusch, MD, Oliver Winz, MSc, Karl Zilles, MD and Andreas Bauer, MD

Institute of Medicine, Research Center Juelich, Juelich, Germany


Figure 1
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  		FIGURE 1.  Representative parametric images of 18F-CPFPX DVt in healthy 46-y-old male volunteer. A through D and E through H were generated by voxelwise graphical analysis without preceding spatial gaussian smoothing and with preceding spatial gaussian smoothing (filter kernel of 5 mm FWHM), respectively. Total scan durations were 90 min (A and E), 75 min (B and F), 60 min (C and G), and 45 min (D and H).

 

Figure 2
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  		FIGURE 2.  Correlations between regional DVt estimates by voxelwise graphical analysis and VOI-based graphical analysis without blood-volume correction (reference method). BVC = blood-volume correction; GA = graphical analysis; PI GA and PI smoothed GA = parametric images generated by voxelwise graphical analysis without spatial gaussian smoothing and with spatial gaussian smoothing (filter kernel of 5 mm FWHM), respectively; solid line is line of identity.

 

Figure 3
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  		FIGURE 3.  Effect of spatial gaussian smoothing on regional DVt estimates given by voxelwise graphical analysis. 2TCM = VOI-based 2TCM with blood-volume correction; BVC = blood-volume correction; ctx. = cortex; GA = graphical analysis; PI GA and PI smoothed GA = parametric images generated by voxelwise graphical analysis without spatial gaussian smoothing and with spatial gaussian smoothing (filter kernel of 5 mm FWHM), respectively.

 

Figure 4
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  		FIGURE 4.  Effect of spatial smoothing on regional noise. Regional noise was calculated as COV of voxel values of specific VOI for each time point. Mean COV of all subjects is plotted as function of time for representative anatomic regions. Three-dimensional gaussian filter (5 mm FWHM) was used for spatial smoothing.

 

Figure 5
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  		FIGURE 5.  Effect of scan duration on quantification accuracy of VOI-based analysis (A and B) and voxelwise graphical analysis (C and D). Illustrated are mean relative deviations of DVt estimates (ordinate) provided by the respective analyses with specified scan durations (abscissa), compared with reference analyses (i.e., 90-min VOI-based 2TCM analysis in A and B, 90-min VOI-based graphical analysis without blood-volume correction in C and D). Mean values (±SD) are given for representative anatomic regions. Times in minutes refer to total scan duration of the respective analyses. BVC = blood-volume correction; GA = graphical analysis; PI GA = parametric image generated by voxelwise graphical analysis without spatial smoothing; PI sGA = parametric image generated by voxelwise graphical analysis after spatial gaussian smoothing (filter kernel of 5 mm FWHM).

 




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