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Lung Toxicity in Radioiodine Therapy of Thyroid Carcinoma: Development of a Dose-Rate Method and Dosimetric Implications of the 80-mCi Rule

George Sgouros1, Hong Song1, Paul W. Ladenson1,2 and Richard L. Wahl1,2

1 Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland; and 2 Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland


Figure 1
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  		FIGURE 1.  Whole-body 48-h activity retention limits for different phantoms and F48 values.

 

Figure 2
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  		FIGURE 2.  Administered activity limits for different phantoms and F48 values as function of TE when TRB is set to 20 h (A) or 10 h (B).

 

Figure 3
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  		FIGURE 3.  Absorbed dose to lungs as function of TE for different F48 values when TRB is set to 20 h (A) or 10 h (B).

 

Figure 4
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  		FIGURE 4.  Absorbed dose vs. TE for adult female phantom for the 2 different remainder-of-body effective clearance half-lives considered. Effective remainder-of-body clearance half-life, TRB, is set to 20 h (A) or 10 h (B).

 




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