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Lack of Correlation of Hypoxic Cell Fraction and Angiogenesis with Glucose Metabolic Rate in Non–Small Cell Lung Cancer Assessed by 18F-Fluoromisonidazole and 18F-FDG PET

Martin H. Cherk1, Serene S. Foo2, Aurora M.T. Poon1, Simon R. Knight3, Carmel Murone2, Anthony T. Papenfuss4, John I. Sachinidis1, Timothy H.C. Saunder1, Graeme J. O'Keefe1 and Andrew M. Scott1,2,5

1 Centre for PET, Austin Hospital, Heidelberg, Victoria, Australia; 2 Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia; 3 Department of Thoracic Surgery, Austin Hospital, Heidelberg, Victoria, Australia; 4 Division of Bioinformatics, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; and 5 Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia


Figure 1
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  		FIGURE 1.  18F-FDG and 18F-FMISO PET scans in patient 12. (A) Intense uniform 18F-FDG uptake in tumor. (B) 18F-FMISO uptake in tumor similar to that of blood pool.

 

Figure 2
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  		FIGURE 2.  18F-FDG and 18F-FMISO PET scans in patient 15. (A) Intense uniform 18F-FDG uptake in tumor. (B) Heterogeneous mildly increased 18F-FMISO uptake with more prominent uptake in periphery of tumor.

 

Figure 3
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  		FIGURE 3.  IHC of tumor biopsies from 2 representative patients. (Top row) Moderately differentiated squamous cell carcinoma (patient 12) with high 18F-FDG uptake and minimal 18F-FMISO uptake on PET studies. (Bottom row) Moderately differentiated adenocarcinoma (patient 15) in which expression of all tumor markers was similar despite higher 18F-FMISO uptake on PET studies. (GLUT1, HIF-1{alpha}, VEGF, and Ki67, x400; VWF, x200)

 




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