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Smoking Cessation Normalizes Coronary Endothelial Vasomotor Response Assessed with ¹⁵O-Water and PET in Healthy Young Smokers

¹ Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ² Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³ Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan; and ⁴ Department of Health Sciences, Hokkaido University, Sapporo, Japan

View larger version (5K): [in this window] [in a new window]   FIGURE 1.  PET data acquisition is shown. MBF was measured at rest and was followed during hyperemic flow–induced adenosine triphosphate (ATP) infusion and CPT.

View larger version (6K): [in this window] [in a new window]   FIGURE 2.  PET scan protocol before and after smoking cessation is shown. ATP = adenosine triphosphate.