HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Parsey, R. V. Articles by Mann, J. J. Search for Related Content PubMed PubMed Citation Articles by Parsey, R. V. Articles by Mann, J. J.

Metabolite Considerations in the In Vivo Quantification of Serotonin Transporters Using ¹¹C-DASB and PET in Humans

¹ Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York; ² Department of Neuroscience, New York State Psychiatric Institute, New York, New York; ³ Department of Biostatistics, Columbia University School of Public Health, New York, New York; and ⁴ Department of Radiology, Columbia University College of Physicians and Surgeons, New York, New York

View larger version (11K): [in a new window]   FIGURE 1.  (A) Average unmetabolized 11C-DASB fraction vs. time for baseline studies. Unlike other ligands, fraction is lower at first time point (2 min) than at second time point (12 min). (B) This lower fraction is caused by lower level of unmetabolized parent compound at 2 min than at 12 min (solid lines) in all but 5 studies (dashed lines).

View larger version (10K): [in a new window]   FIGURE 2.  Time–activity curves for amygdala using ND – 1 (A) and power-function–damped (B) metabolite fits. Time–activity curve fitting using ND – 1metabolite curve fitting is clearly inadequate for early time points. Data are truncated at 60 min; full datasets are shown in insets.

View larger version (6K): [in a new window]   FIGURE 3.  Unmetabolized 11C-DASB fraction vs. time data (circles) fit with ND (A), ND with first metabolite point removed (B), and power-function–damped (C) metabolite fits (lines) for study. ND is clearly inadequate for fitting and will not be used in subsequent analyses.

View larger version (9K): [in a new window]   FIGURE 4.  Graph of weighted residuals vs. time for each metabolite fit, jittered on time axis. Metabolite data were fit with ND – 1 (A) and power-function–damped (B) models.

View larger version (9K): [in a new window]   FIGURE 5.  Comparison of VT values with power-function–damped (PFD) metabolite fit against those determined with ND – 1 using 1-tissue-compartment model (A) and likelihood estimation in graphical approach (B). All regions of interest for all studies are plotted. Line is identity. An outlier is excluded from both graphs.

View larger version (9K): [in a new window]   FIGURE 6.  Plots of unmetabolized 11C-DASB vs. time for same subjects on baseline scan days (A) and occupancy scan days (B). Subjects had plasma sertraline level 13 ng/mL on day of occupancy study. On baseline days, most subjects had lower unmetabolized 11C-DASB at 2 min than at 12 min. After subjects received saturating doses of sertraline, pattern was reversed. Subjects are identified with unique markers.