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Is Septal Glucose Metabolism Altered in Patients with Left Bundle Branch Block and Ischemic Cardiomyopathy?

Kerry Thompson1, George Saab2, David Birnie3, Benjamin J.W. Chow1,4, Heikki Ukkonen5, Karthik Ananthasubramaniam1,6, Robert A. deKemp1, Linda Garrard1, Terrence D. Ruddy1,4, Jean N. DaSilva1 and Rob S.B. Beanlands1,4

1 Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; 2 Department of Diagnostic Radiology, University of Western Ontario, London, Ontario, Canada; 3 Electrophysiology Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; 4 Division of Nuclear Medicine, University of Ottawa, Ottawa, Ontario, Canada; 5 Department of Medicine, Turku University Central Hospital and PET Centre, Turku, Finland; and 6 Henry Ford Hospital, Detroit, Michigan


Figure 1
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  		FIGURE 1.  Examples of septal R-MM +ve (A) and R-MM –ve (B) polar images reflecting perfusion (82Rb) and 18F-FDG uptake across the myocardium. Red reflects maintained tracer uptake, whereas yellow and green reflect decreased tracer uptake. (A) Note reduced septal 18F-FDG uptake with maintained perfusion. (B) Note large lateral wall perfusion defect and corresponding relatively preserved septal wall perfusion and 18F-FDG uptake. A = anterior wall; S = septal wall; L = lateral wall; P = posterior wall.

 

Figure 2
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  		FIGURE 2.  Septal and lateral wall R-MM scores in patients with ICM and LV dysfunction in LBBB and control groups.

 

Figure 3
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  		FIGURE 3.  Mean R-MM score vs. mean QRS duration for control and LBBB lateral (triangles) and septal (squares) walls, with vertical and horizontal SD error bars. *P < 0.001 for LBBB septum vs. LBBB lateral wall, control septum, and control lateral wall.

 

Figure 4
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  		FIGURE 4.  Lateral wall and septal wall mean 82Rb uptake (A) and 18F-FDG uptake (B) for LBBB R-MM –ve and +ve patients only.

 




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