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The Prevalence of Myocardial Ischemia After Concurrent Chemoradiation Therapy as Detected by Gated Myocardial Perfusion Imaging in Patients with Esophageal Cancer

Isis W. Gayed1, H. Helen Liu2, Syed Wamique Yusuf3, Ritusko Komaki4, Xiong Wei2, Xuanmin Wang2, Joe Y. Chang4, Joseph Swafford3, Lyle Broemeling5 and Zhongxing Liao4

1 Department of Nuclear Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 2 Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3 Department of Cardiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 4 Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; and 5 Department of Biostatistics and Applied Mathematics, University of Texas M.D. Anderson Cancer Center, Houston, Texas


Figure 1
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  		FIGURE 1.  Number and location of myocardial perfusion defects in RT group (A) and NRT group (B) in patients with distal esophageal cancer. Sep = septal; Ant/Sep = anteroseptal; Inf = inferior; Inf/Ap = inferoapical; Inf/Sep = inferoseptal; Inf/lat = inferolateral; Lat = lateral; Ant = anterior.

 

Figure 2
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  		FIGURE 2.  Simulation CT slices with RT plan for treating patient with distal esophageal cancer (A) and GMPI images (B) obtained 11 mo after completion of RT. Area of ischemia in inferior wall of heart (arrow) was included in 4,000- to 5,000-cGy isocontours.

 

Figure 3
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  		FIGURE 3.  Correlation of normally perfused myocardium per patient (A) and abnormally perfused myocardium (B) with radiation dose of encompassing RT isodose line in each patient.

 




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