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PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2

Fangyu Peng1–3,, Xin Lu1, James Janisse4, Otto Muzik1,2 and Anthony F. Shields3,5

1 Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan; 2 Department of Radiology, School of Medicine, Wayne State University, Detroit, Michigan; 3 Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan; 4 Center for Healthcare Effectiveness Research, School of Medicine, Wayne State University, Detroit, Michigan; and 5 Department of Medicine, School of Medicine, Wayne State University, Detroit, Michigan


Figure 1
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  		FIGURE 1.  Human prostate cancer xenograft is well visualized on PET image obtained at 24 h after injection. Prominent tracer activity is seen in liver and intestinal tracts in abdomen (excreted activity from liver), with little tracer activity in region of urinary bladder. To allow contrast between organs with a relatively lower %ID/g than that of liver, we expanded color scale at bottom 25% of maximum. Color saturation is seen at location of liver, which has %ID/g of between 15% and 20%.

 

Figure 2
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  		FIGURE 2.  Distribution of 64CuCl2 as determined by radioactivity assay in athymic mice bearing human prostate cancer xenografts. Postmortem tissues were harvested at 1 h (n = 5) or 24 h (n = 5) after intravenous injection of tracer. In comparison to tracer concentrations obtained at 1 h after injection, tracer concentrations obtained at 24 h after injection were higher in tumor and spleen tissues but lower in other tissues.

 

Figure 3
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  		FIGURE 3.  Strong hCtr1 immunoreactivity is seen on this section of human prostate cancer xenograft tissues after incubation with polyclonal antibody specific for hCtr1 (brown horseradish peroxidase product) (A) but was not seen on tissue sections of negative control. (B) Tissue sections were counterstained with DAPI (blue) to show cell nuclei.

 




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