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Monitoring Left Ventricular Dilation in Mice with PET

Lars Stegger, PhD1, Klaus P. Schäfers, PhD1, Ulrich Flögel, PhD2, Lefteris Livieratos, PhD3, Sven Hermann, MD1, Christoph Jacoby, PhD2, Petra Keul, PhD4, Edward M. Conway, MD5, Otmar Schober, MD, PhD1, Jürgen Schrader, MD2, Bodo Levkau, MD4 and Michael Schäfers, MD1

1 Department of Nuclear Medicine, University Hospital Münster, Münster, Germany
2 Institute of Heart and Circulation Physiology, University Hospital Düsseldorf, Düsseldorf, Germany
3 Department of Nuclear Medicine, Guy’s & St Thomas’ Hospitals, London, United Kingdom
4 Institute of Pathophysiology, Center for Internal Medicine, University Hospital Essen, Essen, Germany
5 Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium



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  		FIGURE 1. PET and MR images depict a short-axis slice through the heart of a wild-type mouse (A) with normal heart size and a transgenic mouse (B) with dilated left ventricle. MR images shown were acquired in end-diastole.

 


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  		FIGURE 2. Midmyocardial (solid line) and endo- or epicardial (dashed lines) contours superimposed on 18F-FDG PET short-axis image (A) and vertical long-axis image (B) of mouse heart as measured by PET. Only the midmyocardial contour is used in this study.

 


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  		FIGURE 3. Comparison of LV volume indices LV-VIPET/MRI (in µL) measured by PET and MRI. Equal fractional contributions of end-diastolic or end-systolic volumes were used for LV-VIMRI (xED = xES = 0.5). (A) Scatter plot of LV volume indices measured by PET vs. MRI. Confidence curves for regression fit as well as confidence curves of individual values are also shown (dashed lines, {alpha} = 0.05). (B) Difference of PET and MRI measurements plotted against the mean of both measurements. Horizontal lines for mean (solid) and mean ± 2 SD (dashed) are included. Values for linear fit (intercept, 30.0; slope, 0.011) are not shown.

 




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