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¹²³I-5-IA-85380 SPECT Measurement of Nicotinic Acetylcholine Receptors in Human Brain by the Constant Infusion Paradigm: Feasibility and Reproducibility

¹ Department of Psychiatry, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut
² Institute for Neurodegenerative Disorders, New Haven, Connecticut

View larger version (19K): [in a new window]   FIGURE 1. Two-dimensional standardized regions of interest are placed on 3 representative transverse images of 123I-5-IA uptake. FC = frontal cortex; PC = parietal cortex; mFC = medial frontal cortex; TIC = temporoinsular cortex; AC = anterior cingulate; OC = occipital cortex; Cd = caudate; Th = thalamus; Pt = putamen; CB = cerebellum.

View larger version (13K): [in a new window]   FIGURE 2. Total plasma parent (•, ) and free parent (, ) 123I-5-IA activity are illustrated for test (filled symbols) and retest (open symbols) of representative subject. 123I-5-IA was administered using bolus-plus-constant-infusion paradigm (bolus-to-infusion ratio = 6.94 and 6.96 for test and retest studies, respectively).

View larger version (12K): [in a new window]   FIGURE 3. 123I-5-IA activity in thalamus (•, ), striatum (, ), and cortex (, ) is illustrated for test (filled symbols) and retest (open symbols) of representative subject.