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Comparison of Monoamine Oxidase A in Peripheral Organs in Nonsmokers and Smokers

¹ Chemistry Department, Brookhaven National Laboratory, Upton, New York
² Medical Department, Brookhaven National Laboratory, Upton, New York
³ National Institute on Drug Abuse, Bethesda, Maryland
⁴ Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York
⁵ Department of Radiology, State University of New York at Stony Brook, Stony Brook, New York

View larger version (10K): [in a new window]   FIGURE 1. Structures of 11C-clorgyline and 11C-clorgyline-D2. The C—H (C—D) bond in the methylene carbon of the propargyl group is the one that is cleaved in the rate-contributing step of MAO-catalyzed oxidation.

View larger version (19K): [in a new window]   FIGURE 2. Time–activity curves for nonsmokers and smokers for 11C-clorgyline for arterial plasma for the first 5 min after injection corrected for the presence of labeled metabolites (A) and for lungs over a 52-min experimental period (B). Note that smokers have reduced arterial input as well as slower lung clearance of 11C. A similar pattern is seen for 11C-clorgyline-D2 (31). (Adapted with permission of (31).)