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Quantitative Dynamic Cardiac 82Rb PET Using Generalized Factor and Compartment Analyses

Georges El Fakhri, PhD1, Arkadiusz Sitek, PhD2, Bastien Guérin, MSc1, Marie Foley Kijewski, ScD1, Marcelo F. Di Carli, MD1 and Stephen C. Moore, PhD1

1 Division of Nuclear Medicine, Department of Radiology, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts
2 Ernest Orlando Lawrence Berkeley National Laboratories, Berkeley, California



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  		FIGURE 1. Simulated RV and LV input functions and associated myocardial TACs corresponding to 3 different sets of values of k1 (mL/min/g) and k2 (min–1) as well as corresponding factors estimated with GFADS (open symbols). MYO = myocardium.

 


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  		FIGURE 2. Estimated factors with VOI TACs and GFADS and GFADS-derived factor images. The 3-factor images were well separated with GFADS, whereas the LV+RV input functions were underestimated and the myocardial (MYO) TAC was overestimated with VOI TACs, due to spillover in early time points.

 


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  		FIGURE 3. Estimated factors and factor images (3 transverse slices) with GFADS for a typical dynamic 82Rb PET study in 93-y-old female with known CAD but with normal myocardial perfusion (SSS = 0). Radioactive decay was not compensated. LV, RV, and myocardium (MYO) were well separated using our uniqueness constraint.

 


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  		FIGURE 4. Parametric maps of myocardial tissue extraction (k1) and egress (k2) as well as RV and LV contributions (fvi, rvi) from the patient dynamic study shown in Figure 3. Note absence of aberrant points due to orthogonal grouping.

 




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