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Parametric Imaging of Myocardial Blood Flow with ¹⁵O-Water and PET Using the Basis Function Method

¹ Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka, Japan
² Research Laboratories, Kyoto Pharmaceutical Industries, Ltd., Kyoto, Japan
³ SHI Accelerator Service Ltd., Tokyo, Japan

View larger version (34K): [in a new window]   FIGURE 1. Examples of parametric images of MBFt (A), MBFp (B), perfusable tissue fraction (C), and Va (D) under resting conditions (left) and under a 1 µg/kg/min (center) or 5 µg/kg/min (right) dose of CGS-21680.

View larger version (28K): [in a new window]   FIGURE 2. Comparison of MBFt (top left), MBFp (top right), perfusable tissue fraction (bottom left), and Va (bottom right) values estimated using nonlinear least-squares method (NLM) with those estimated using basis function method (BFM).

View larger version (37K): [in a new window]   FIGURE 3. Four representative slices of functional images (MBFt, MBFp, perfusable tissue fraction [PTF], and Va) obtained by basis function method (BFM) and nonparametric bootstrap technique. Mean images (left) and coefficient-of-variance images (%COV, right) were generated from 10 statistically independent replicates.