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5-HT1A Receptors Are Reduced in Temporal Lobe Epilepsy After Partial-Volume Correction

Giampiero Giovacchini, MD, PhD1,2, Maria T. Toczek, MD3, Robert Bonwetsch, MD3, Anto Bagic, MD3, Lixin Lang, PhD1, Charles Fraser, MS1, Pat Reeves-Tyer, MS3, Peter Herscovitch, MD1, William C. Eckelman, PhD1, Richard E. Carson, PhD1 and William H. Theodore, MD3

1 PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland
2 Postgraduate Specialty School in Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
3 Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, National Institutes of Health, Bethesda, Maryland



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  		FIGURE 1. Coronal T2-weighted (A, top) and T1-weighed (A, bottom) MR images of patient with TLE with a right mesial temporal focus and coregistered 18F-FCWAY distribution volume (V/f1, B) and CMRglu (C) images before (top) and after (bottom) PVC. Coronal images are at level of posterior hippocampus, anterior to pons. V/f1 and CMRglu images are scaled to a maximum of 100 mL/mL and 10 mg/min/100 g, respectively.

 


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  		FIGURE 2. Relationship between percentage increase in 18F-FCWAY distribution volume (V/f1, mL/mL) and CMRglu (mg/min/100 g) in TLE patients. Each point represents mean ROI value. Regression equation was V = 21.5 + 0.90 CMRglu; r2 = 0.95; P < 0.001. Dashed line represents identity line.

 


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  		FIGURE 3. Relationship between 18F-FCWAY BP (mL/mL) in hippocampus ipsilateral to seizure focus and BDI scale score in TLE patients before (A) and after (B) PVC. Regression equations were y = 47.6 –1.24x; r2 = 0.35, P = 0.004 (A) and y = 81.2 –1.97x; r2 = 0.26, P = 0.016 (B).

 




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