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Quantification of ¹²³I-PE2I Binding to Dopamine Transporter with SPECT After Bolus and Bolus/Infusion

¹ Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
² Department of Anesthesia, University Hospital Rigshospitalet, Copenhagen, Denmark

View larger version (66K): [in a new window]   FIGURE 1. 123I-PE2I SPECT image obtained from 2 to 3 h after tracer injection in healthy subject.

View larger version (15K): [in a new window]   FIGURE 2. Average 123I-PE2I bolus data: time course for metabolite-corrected plasma radioactivity (A), time course for striatum and occipital cortex radioactivity (B), time course for (Ctot – Cref)/C1 (C), and time course for (Ctot – Cref)/Cref (D).

View larger version (9K): [in a new window]   FIGURE 3. (A) Average (with SD) normalized BP1(t) in striatum calculated using 2-tissue-compartment analysis and Logan analysis with metabolite-corrected plasma as input function. (B) Average (with SD) normalized BP2(t) in striatum calculated using simplified reference tissue analysis and Logan analysis with occipital cortex as input function. Normalization was performed by dividing value at each time point by value at 180 min. For each method of analysis, average BP1 and BP2 were calculated by deleting a progressive number of frames from end of study.

View larger version (16K): [in a new window]   FIGURE 4. Average 123I-PE2I bolus/infusion data: time course for metabolite-corrected plasma radioactivity (A), time course for striatum and occipital cortex radioactivity (B), time course for (Ctot – Cref)/C1 (C), and time course for (Ctot – Cref)/Cref (D).

View larger version (19K): [in a new window]   FIGURE 1A. Computer simulations of outcome parameters after bolus plus constant infusion of radiotracer. See text for details.