Clinical Testing of an Optimized Software Solution for an Automated, Observer-Independent Evaluation of Dopamine Transporter SPECT Studies
Walter Koch, MD1,
Perry E. Radau, PhD2,
Christine Hamann, MD3 and
Klaus Tatsch, MD1
1 Department of Nuclear Medicine, University of Munich, Munich, Germany
2 Department of Medical Biophysics, Sunnybrook & Women’s College Health Sciences, Toronto, Ontario, Canada
3 Department of Neurology, University of Munich, Munich, Germany
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FIGURE 1. Mean template of healthy control subjects (A and C) and corresponding 3D VOI map (B) for semiquantitative evaluation.
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FIGURE 2. Example for manual semiquantification technique. Predefined 2D ROIs are placed manually to match entire striatum, caudate, and putamen (regions 1–6). In addition, a freehand ROI is drawn as occipital reference (region 7).
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FIGURE 3. Example of a patient scan adequately registered to template with VOIs placed correctly (A) and a scan with inadequate registration (insufficient scaling) and imprecise VOI placement requiring manual correction (B). White line marks surface of the patient head of registration template used.
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FIGURE 4. Correlation graphs of specific binding ratios obtained with manual and automatic semiquantification method (P < 0.001 in all 4 diagrams; 155 subjects, left and right striatum of all subjects included as separate data points). Corresponding regression line parameters are listed in Table 3. P-to-C ratio = putamen-to-caudate ratio.
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Copyright © 2005 by the Society of Nuclear Medicine.
